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HBcrAg predicts hepatocellular carcinoma development: An analysis using time-dependent receiver operating
Toshifumi Tada1, Takashi Kumada1, Hidenori Toyoda1
1Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
Journal of Hepatology
|April 2, 2016
Summary
Hepatitis B core-related antigen (HBcrAg) is a strong predictor of liver cancer (HCC) in chronic hepatitis B patients. This marker shows greater predictive power for HCC development than HBV DNA.
Area of Science:
- Hepatology
- Virology
- Oncology
Background:
- Chronic hepatitis B (CHB) patients have an increased risk of developing hepatocellular carcinoma (HCC).
- Several hepatitis B virus (HBV) markers are associated with HCC development, but their predictive power requires clarification.
Purpose of the Study:
- To clarify the predictive power of HBV markers for HCC development in CHB patients.
- To compare the predictive accuracy of different HBV markers using time-dependent receiver operating characteristic (ROC) analysis.
Main Methods:
- 1031 CHB patients not receiving nucleos(t)ide analogue therapy were enrolled.
- Univariate, multivariate, and time-dependent ROC analyses were performed for HBV markers.
- Key markers analyzed included HBV genotype, HBV DNA, HBcrAg, HBeAg, and BCP mutation.
Main Results:
- 78 patients developed HCC during a median 10.7-year follow-up.
- HBV core-related antigen (HBcrAg) >2.9logU/ml and BCP mutation were independently associated with HCC incidence.
- Time-dependent ROC analysis revealed HBcrAg demonstrated superior predictive power for HCC development compared to HBV DNA.
Conclusions:
- Elevated HBcrAg levels are significantly associated with HCC development in CHB patients.
- HBcrAg is an excellent and superior predictor of HCC development in this patient cohort.
Keywords:
Hepatitis BHepatitis B virus core-related antigenHepatocellular carcinomaTime-dependent receiver operating characteristicMore Related Videos
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