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Complete Genome Sequence of Streptococcus pneumoniae Serotype 19A, a Blood Clinical Isolate from Northeast Mexico

Antonio Ali Perez-Maya1, Rosa Maria Hinojosa-Robles2, Jose Ramon Barcenas-Walls3

  • 1Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Genome Announcements
|April 2, 2016
PubMed

Insights

We sequenced the genome of a multidrug-resistant Streptococcus pneumoniae strain from Mexico. This invasive serogroup 19A strain, MTY1662SN214, was isolated from a patient with purpura fulminans.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Streptococcus pneumoniae is a leading cause of bacterial infections worldwide.
  • Invasive and multidrug-resistant strains pose significant public health challenges.
  • Purpura fulminans is a rare, severe complication associated with certain bacterial infections.

Purpose of the Study:

  • To report the draft genome sequence of a novel Streptococcus pneumoniae strain.
  • To characterize the genetic features of an invasive, multidrug-resistant strain isolated from a purpura fulminans case.

Main Methods:

  • Whole-genome sequencing was performed on the isolated strain MTY1662SN214.
  • Bioinformatic analysis was used to assemble the draft genome and determine its characteristics.

Main Results:

  • The draft genome sequence of Streptococcus pneumoniae strain MTY1662SN214 was generated.
  • The strain belongs to the invasive and multidrug-resistant serogroup 19A, sequence type 320 (ST320).
  • The genome consists of 60 contigs, totaling 2,069,474 bp with a G+C content of 39.7%.

Conclusions:

  • This study provides the first draft genome sequence of a Streptococcus pneumoniae strain from Monterrey, Mexico, associated with purpura fulminans.
  • The genomic data will aid in understanding the evolution and epidemiology of invasive and multidrug-resistant S. pneumoniae strains.

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