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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Autonomic Nervous System01:22

Autonomic Nervous System

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The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
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Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
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Autonomic Nervous System: Overview01:26

Autonomic Nervous System: Overview

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The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
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Related Experiment Video

Updated: Mar 23, 2026

In Vivo Telemetry to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in Spinal Cord Injury Rat Models
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Cardiovascular autonomic neuropathy.

Niamh McCarty1, Barry Silverman1

  • 1Division of Cardiovascular Medicine, Northside Hospital, Atlanta, Georgia.

Proceedings (Baylor University. Medical Center)
|April 2, 2016
PubMed
Summary

Cardiovascular autonomic neuropathy in type 1 diabetes can be severe and multifaceted. Early identification and aggressive management of diabetes are crucial for improving patient outcomes and addressing symptoms.

Area of Science:

  • Endocrinology
  • Neurology
  • Cardiology

Background:

  • Cardiovascular autonomic neuropathy (CAN) is a serious complication of diabetes.
  • It often presents subtly and can be overlooked.
  • Early diagnosis is critical for effective management.

Observation:

  • A 22-year-old male with type 1 diabetes developed multiple CAN symptoms 2 years post-diagnosis.
  • Symptoms included weakness, dizziness, fatigue, tachycardia, abnormal QTc, and orthostasis.
  • He showed signs of both parasympathetic (resting tachycardia, exercise intolerance) and sympathetic (orthostatic hypotension) denervation.

Findings:

  • The patient experienced significant autonomic dysfunction affecting both heart rate regulation and blood pressure.
  • Despite incomplete autonomic reflex testing, his condition improved with intensified diabetes treatment and adjusted beta-blockade.

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  • This case highlights the complex and varied presentation of CAN in young diabetic patients.

    • Implications:

    • Highlights the importance of recognizing and diagnosing cardiovascular autonomic neuropathy in type 1 diabetes.
    • Underscores the need for comprehensive autonomic function assessment in diabetic patients with suggestive symptoms.
    • Emphasizes the potential benefits of aggressive diabetes control and targeted pharmacotherapy in managing CAN.