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Updated: Mar 23, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid hormone resistance and its management
Ana Marcella Rivas1, Joaquin Lado-Abeal1
1Department of Medicine, Division of Endocrinology and Metabolism, Mayo Clinic, Jacksonville, Florida (Rivas); and the Department of Medicine, Division of Endocrinology, Texas Tech University Health Science Center, Lubbock, Texas (Lado-Abeal).
Abstract:
The syndrome of impaired sensitivity to thyroid hormone, also known as syndrome of thyroid hormone resistance, is an inherited condition that occurs in 1 of 40,000 live births characterized by a reduced responsiveness of target tissues to thyroid hormone due to mutations on the thyroid hormone receptor. Patients can present with symptoms of hyperthyroidism or hypothyroidism. They usually have elevated thyroid hormones and a normal or elevated thyroid-stimulating hormone level. Due to their nonspecific symptomatic presentation, these patients can be misdiagnosed if the primary care physician is not familiar with the condition. This can result in frustration for the patient and sometimes unnecessary invasive treatment such as radioactive iodine ablation, as in the case presented herein.
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