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Related Concept Videos

Spinal Cord01:26

Spinal Cord

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The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
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The Spinal Cord01:54

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The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
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Spinal Cord: Gross Anatomy01:15

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The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
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Spinal Cord: Cross-sectional Anatomy01:16

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The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
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Spinal Cord: Information Processing01:10

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The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
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Related Experiment Video

Updated: Mar 23, 2026

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
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Acute spinal cord injury.

W Kirke Rogers1, Michael Todd1

  • 1Department of Anesthesia, University of Iowa Hospital and Clinics, Iowa City, IA, USA.

Best Practice & Research. Clinical Anaesthesiology
|April 3, 2016
PubMed
Summary

Acute spinal cord injury (SCI) causes severe motor and sensory deficits. Interventions like surgery and methylprednisolone aim to mitigate secondary injury and improve outcomes.

Keywords:
GM-1 gangliosideanesthesiacervical cordmethylprednisolonespinal cord compressionspinal cord injuriestrauma, nervous system

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Area of Science:

  • Neurology
  • Neurosurgery
  • Trauma Care

Background:

  • Acute spinal cord injury (SCI) results in significant mortality and morbidity.
  • SCI pathophysiology involves an initial insult followed by secondary ischemic damage.
  • The secondary injury phase presents a potential window for therapeutic intervention.

Purpose of the Study:

  • To review procedural and pharmacologic interventions for acute spinal cord injury.
  • To explore strategies aimed at improving motor and sensory outcomes post-SCI.

Main Methods:

  • Review of literature on interventions for acute spinal cord injury.
  • Discussion of early decompressive surgery.
  • Examination of methylprednisolone use and management of blood pressure and respiration.

Main Results:

  • Early decompressive surgery is a proposed intervention.
  • Methylprednisolone has been studied for its effects on SCI.
  • Optimized blood pressure and respiratory management are considered crucial.

Conclusions:

  • The secondary injury process in SCI is modifiable.
  • Various interventions show potential for improving functional outcomes after SCI.
  • Multimodal management strategies are key to mitigating SCI severity.