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Updated: Mar 23, 2026

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

EAGER: efficient ancient genome reconstruction.

Alexander Peltzer^1,2,3, Günter Jäger⁴, Alexander Herbig^4,5,6

¹Center for Bioinformatics (ZBIT), Integrative Transcriptomics, Eberhard-Karls-Universität, Sand 14, Tübingen, 72076, Germany. alexander.peltzer@uni-tuebingen.de.

|April 3, 2016

Summary

This summary is machine-generated.

EAGER is a new pipeline simplifying ancient DNA analysis. It integrates tools for efficient data processing, quality assessment, and variant discovery in ancient genomes.

Keywords:

Authentication Bioinformatics Genome reconstruction aDNA aDNA analysis

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Optimized Bone Sampling Protocols for the Retrieval of Ancient DNA from Archaeological Remains

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Published on: November 30, 2021

Area of Science:

Genomics
Bioinformatics
Ancient DNA Analysis

Background:

Automated genome sequence reconstruction in ancient DNA analysis is complex.
Handling large-scale ancient genomic datasets presents significant challenges.

Purpose of the Study:

To introduce EAGER, a time-efficient pipeline for ancient DNA analysis.
To simplify the processing and analysis of large-scale ancient genomic data.

Main Methods:

EAGER integrates state-of-the-art and novel tools for ancient DNA data.
The pipeline includes features for data preprocessing, mapping, and quality assessment.
Tools for genotyping, variant discovery, filtering, and analysis are incorporated.

Main Results:

EAGER significantly simplifies the analysis of large-scale ancient genomic datasets.
The pipeline enables efficient preprocessing, mapping, authentication, and quality assessment of ancient DNA samples.
EAGER facilitates sample genotyping and variant analysis, including discovery and filtering.

Conclusions:

EAGER offers an integrated solution for ancient DNA analysis.
It combines existing and new tools tailored for ancient DNA data.
The pipeline provides an easily accessible format for researchers.