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Updated: Mar 23, 2026

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
Published on: September 3, 2009
EAGER: efficient ancient genome reconstruction
Alexander Peltzer1,2,3, Günter Jäger4, Alexander Herbig4,5,6
1Center for Bioinformatics (ZBIT), Integrative Transcriptomics, Eberhard-Karls-Universität, Sand 14, Tübingen, 72076, Germany. alexander.peltzer@uni-tuebingen.de.
Background:
The automated reconstruction of genome sequences in ancient genome analysis is a multifaceted process.
Results:
Here we introduce EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets. EAGER provides features to preprocess, map, authenticate, and assess the quality of ancient DNA samples. Additionally, EAGER comprises tools to genotype samples to discover, filter, and analyze variants.
Conclusions:
EAGER encompasses both state-of-the-art tools for each step as well as new complementary tools tailored for ancient DNA data within a single integrated solution in an easily accessible format.
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