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Genetic insights into the mechanisms of Fgf signaling

J Richard Brewer1, Pierre Mazot1, Philippe Soriano1

  • 1Department of Developmental and Regenerative Biology, Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, New York 10029, USA.

Genes & Development
|April 3, 2016
PubMed

Insights

Fibroblast growth factor (Fgf) signaling is crucial for development and adult health. Genetic studies reveal Erk1/2 is a key mediator, but other pathways also transmit Fgf signals in vivo.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Fibroblast growth factor (Fgf) signaling is vital for embryonic and adult biological processes.
  • Dysregulated Fgf signaling contributes to congenital disorders and various cancers.

Purpose of the Study:

  • To review the mechanisms governing Fgf signaling.
  • To highlight the role of genetic strategies in analyzing Fgf signaling in vivo.

Main Methods:

  • Review of genetic strategies for in vivo analysis of Fgf signaling.
  • Examination of studies investigating Fgf signaling pathways.

Main Results:

  • Erk1/2 is confirmed as a significant mediator of Fgf signaling across numerous biological processes.
  • Evidence suggests additional signaling pathways are involved in transmitting Fgf signals in vivo.

Conclusions:

  • Understanding Fgf signaling mechanisms is essential for comprehending Fgf biology and associated diseases.
  • In vivo genetic analyses provide critical insights into the complexity of Fgf signal transduction.
Keywords:
Erk1/2Fgfrfibroblast growth factorreceptor tyrosine kinasesignaling

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