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Published on: July 19, 2019
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Exploring the overlap between multiple sclerosis, tumefactive demyelination and Baló's concentric sclerosis
Todd A Hardy1, W Oliver Tobin2, Claudia F Lucchinetti2
1Neuroimmunology Clinic, Department of Neurology, Concord Repatriation General Hospital, University of Sydney, Concord West, NSW, Australia/Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia thardy@med.usyd.edu.au.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 3, 2016
Summary
Multiple sclerosis (MS), tumefactive demyelination (TD), and Baló's concentric sclerosis (BCS) share overlapping features. Understanding these demyelinating diseases may offer insights into MS immunopathogenesis.
Area of Science:
- Neuroimmunology
- Neuropathology
- Radiology
Background:
- Magnetic resonance imaging (MRI) reveals overlapping features among multiple sclerosis (MS), tumefactive demyelination (TD), and Baló's concentric sclerosis (BCS).
- Baló-like lesions may represent an intermediate phenotype between BCS and typical MS.
- Tumefactive lesions, though larger, share commonalities with conventional MS lesions, and TD and BCS lesions also overlap.
Purpose of the Study:
- To explore similarities between typical MS, TD, and BCS.
- To investigate insights from intermediate or overlapping phenotypes into MS immunopathogenesis.
- To question the classification of these atypical demyelinating forms.
Main Methods:
- Comparative analysis of MRI features in MS, TD, and BCS.
- Review of existing literature on demyelinating diseases.
- Pathophysiological correlation of lesion characteristics.
Main Results:
- Significant overlap exists in lesion characteristics across MS, TD, and BCS.
- Intermediate phenotypes suggest a potential spectrum of demyelination.
- Atypical forms share features with conventional MS lesions.
Conclusions:
- The distinct classification of TD and BCS as separate diseases warrants re-evaluation.
- These conditions may represent variations within a broader spectrum of demyelination.
- Further research into overlapping phenotypes can illuminate MS immunopathogenesis.
