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Related Concept Videos

Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Master Transcription Regulators02:23

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Related Experiment Video

Updated: Mar 23, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Emerging Roles of Epigenetic Regulator Sin3 in Cancer.

N Bansal1, G David2, E Farias1

  • 1The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Advances in Cancer Research
|April 3, 2016
PubMed
Summary

Targeting Sin3 proteins, which regulate gene transcription, offers a promising strategy for developing novel cancer therapies. Research highlights their role in various cancers and proposes new screening methods for Sin3-targeting antitumor agents.

Keywords:
Cancer stem cellsEpigeneticsHDACMultiple endocrine neoplasia type 2Pancreatic ductal adenocarcinomaSin3ASin3BTriple negative breast cancer

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Area of Science:

  • Epigenetics and Molecular Biology
  • Cancer Pathogenesis and Therapeutics

Background:

  • Chromatin-associated proteins are emerging as critical targets for innovative cancer treatments.
  • There is a pressing need for targeted epigenetic inhibitors with improved safety profiles.
  • The Sin3 family (Sin3A/B) comprises conserved global transcription regulators involved in essential cellular functions and implicated in cancer.

Purpose of the Study:

  • To review the fundamental biology of Sin3 proteins.
  • To summarize recent findings on the role of Sin3 proteins in cancer development.
  • To present a novel strategy for screening anticancer agents targeting chromatin-associated factors like Sin3.

Main Methods:

  • Literature review of Sin3 biology and its role in cancer.
  • Analysis of Sin3 protein involvement in specific cancer types (MEN2, PDAC, TNBC).
  • Proposal of an integrative screening program for chromatin-associated factor-targeting agents.

Main Results:

  • Sin3 proteins are global transcription regulators influencing cell cycle, proliferation, and differentiation.
  • Sin3 proteins play a significant role in the pathogenesis of multiple endocrine neoplasia type 2, pancreatic ductal adenocarcinoma, and triple-negative breast cancer.
  • An integrative approach for screening Sin3-targeting antitumor agents has been proposed.

Conclusions:

  • Sin3 proteins represent a promising therapeutic target for cancer treatment.
  • Targeted inhibition of Sin3A/B may offer a strategy for developing novel, less toxic anticancer drugs.
  • The proposed screening program aims to accelerate the discovery of effective Sin3-targeting agents.