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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Interventions for acne scars.

Rania Abdel Hay1, Khalid Shalaby, Hesham Zaher

  • 1Department of Dermatology, Faculty of Medicine, Cairo University, 13th Abrag Othman, Kournish el Maadi, Cairo, Egypt, 11431.

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|April 3, 2016
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This summary is machine-generated.

This review found limited high-quality evidence for acne scar treatments, with injectable fillers showing moderate evidence for atrophic scars. Further research is needed to establish long-term efficacy and compare treatments against placebo.

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Area of Science:

  • Dermatology
  • Evidence-based medicine
  • Cosmetic procedures

Background:

  • Acne scarring is a common sequela of acne, impacting psychosocial well-being.
  • A lack of high-quality evidence exists for effective and safe acne scar treatments.
  • This review focuses on treatments for facial atrophic acne scars.

Purpose of the Study:

  • To systematically assess the effects of interventions for treating acne scars.
  • To evaluate participant-reported scar improvement and adverse effects.

Main Methods:

  • Searched multiple databases up to November 2015 for randomized controlled trials (RCTs).
  • Included RCTs comparing active interventions for acne scars, excluding keloid scars.
  • Extracted data, assessed risk of bias, and analyzed primary outcomes: scar improvement and serious adverse effects.

Main Results:

  • Included 24 trials with 789 adult participants; eight studies had low risk of bias in key areas.
  • Fractional laser showed potential benefits over non-fractional laser; injectable fillers demonstrated moderate evidence for improvement.
  • Pain was a common short-term adverse event across multiple treatments; chemical peeling had a higher risk of hyperpigmentation.

Conclusions:

  • A significant lack of high-quality evidence exists due to methodological limitations and small study sizes.
  • Injectable fillers show moderate evidence for atrophic acne scars, but long-term effects are unknown.
  • Current evidence does not support the first-line use of any specific intervention; placebo-controlled trials are recommended.