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Updated: Mar 23, 2026
07:11
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Impaired Right Ventricular Function in Long-Term Lymphoma Survivors
Klaus Murbraech1, Espen Holte2, Kaspar Broch1
1Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Summary
Cardiotoxicity from cancer treatments significantly impairs right ventricular (RV) function in adult survivors. This long-term cardiac effect impacts RV performance, highlighting the need for monitoring RV function post-treatment.
Area of Science:
- Cardiology
- Oncology
- Cardiovascular Research
Background:
- Cardiotoxicity from cancer therapies like anthracyclines and radiation negatively impacts left ventricular (LV) function.
- Long-term effects on right ventricular (RV) performance following such treatments remain largely uncharacterized.
Purpose of the Study:
- To investigate the long-term impact of cardiotoxic cancer treatments on RV function in adult cancer survivors.
- To compare RV performance in lymphoma survivors (LSs) with age- and gender-matched controls.
Main Methods:
- Evaluated 274 adult lymphoma survivors (LSs) who underwent autologous hematopoietic stem cell transplantation using echocardiography and cardiopulmonary exercise testing.
- Compared echocardiographic parameters of LSs with a large Norwegian control database.
- Defined RV systolic dysfunction by ≥2 abnormal RV systolic parameters and LV systolic dysfunction by LV global longitudinal strain > -17%.
Main Results:
- All RV systolic function parameters were significantly impaired in LSs compared to controls (P < .01).
- Tricuspid annular plane systolic excursion was notably reduced in LSs (22.9 ± 4.1 mm vs. 27.1 ± 4.2 mm).
- Higher cardiotoxic treatment burden correlated with greater RV functional impairment; RV function correlated with LV function, though LV dysfunction was more prevalent (30.8%) than RV dysfunction (6.2%).
Conclusions:
- Right ventricular systolic function is impaired in adult lymphoma survivors long after treatment.
- The correlation between RV and LV function suggests a global, long-term cardiotoxic effect.
- While RV dysfunction was observed, it was less prevalent than left ventricular dysfunction in this cohort.
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