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PNPLA3 gene in liver diseases

Eric Trépo1, Stefano Romeo2, Jessica Zucman-Rossi3

  • 1Inserm, UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Institut Universitaire d'Hématologie, Paris, France; Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium; Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.

Journal of Hepatology
|April 4, 2016
PubMed
Summary

A specific gene variant (rs738409 C>G p.I148M) in patatin-like phospholipase domain containing 3 (PNPLA3) is strongly linked to nonalcoholic fatty liver disease and its progression. Understanding liver fat metabolism is crucial for predicting liver disease outcomes.

Keywords:
FibrosisGenetic association studiesHepatocellular carcinomaHeritabilitySteatosisTriglycerides

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