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Updated: Mar 23, 2026

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
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Changes in Brown Adipose Tissue and Muscle Development during Infancy

Skorn Ponrartana1, Patricia C Aggabao1, Thomas A Chavez2

  • 1Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA.

The Journal of Pediatrics
|April 4, 2016
PubMed

Insights

Brown adipose tissue (BAT) changes are linked to muscle growth in infants, but not white adipose tissue (WAT) gain. Further research is needed to understand BAT

Area of Science:

  • Human Physiology
  • Developmental Biology
  • Metabolic Health

Background:

  • Brown adipose tissue (BAT) and muscle share developmental origins.
  • Understanding their interplay is crucial for infant development.
  • Postnatal development involves significant tissue remodeling.

Purpose of the Study:

  • To investigate the relationship between brown adipose tissue (BAT) and muscle development in infants.
  • To analyze changes in BAT and musculature during the first six months of life.
  • To determine if BAT influences muscle growth or white adipose tissue (WAT) accumulation.

Main Methods:

  • Whole-body magnetic resonance imaging (MRI) in 30 healthy term infants.
  • Measurements of supraclavicular BAT, trunk musculature, and subcutaneous WAT at birth and 6 months.
  • Statistical analysis to assess correlations and predictive relationships.

Main Results:

  • Paraspinous musculature and subcutaneous WAT increased, while supraclavicular BAT proportion decreased.
  • BAT was a significant predictor of paraspinous musculature, independent of weight, length, and WAT.
  • Infants with less BAT decrease showed greater muscle gain; BAT changes did not predict WAT accumulation.

Conclusions:

  • Changes in brown adipose tissue are associated with infant muscle development.
  • Brown adipose tissue does not appear to influence white adipose tissue accumulation in infancy.
  • Further studies are required to elucidate the mechanisms linking BAT to muscle growth and its clinical implications for low birth weight infants.
Abstract

Keywords:
MRIbrown fatinfantsmusculature

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