Human Beige Adipocytes: Epiphenomenon or Drivers of Metabolic Improvements?

There is a lack of direct evidence that human brown or beige adipocytes improve whole-body energy homeostasis. In a recent study, Min et al. implanted proliferated human adipocyte progenitors from a 3D culture system in mice. Implants responded to adipogenic stimuli and had a beige-like phenotype upon induction that significantly improved systemic metabolic parameters.