Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.5K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.3K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

920
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
920
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

1.2K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.2K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

569
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
569
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

652
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
652

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three cases of hypertension-related events who were not treated as 'white-coat hypertension'.

Blood pressure monitoring·2026
Same author

Validity of risk stratification of JSH 2025 guideline based on hypertensive retinal changes.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same author

Successful Immunosuppressive Therapy for Aseptic Abscess Syndrome Presenting with a Fever of Unknown Origin.

Internal medicine (Tokyo, Japan)·2026
Same author

Lack of impact of ipragliflozin on endothelial function in patients with type 2 diabetes: sub-analysis of the PROTECT study.

Cardiovascular diabetology·2023
Same author

Influence of left ventricular ejection fraction on the reduction in N-terminal pro-brain natriuretic peptide by canagliflozin in patients with heart failure and type 2 diabetes: A sub analysis of the CANDLE trial.

Journal of cardiology·2022
Same author

Effect of ipragliflozin on carotid intima-media thickness in patients with type 2 diabetes: a multicenter, randomized, controlled trial.

European heart journal. Cardiovascular pharmacotherapy·2022

Related Experiment Video

Updated: Mar 23, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K

Riser Pattern: Another Determinant of Heart Failure With Preserved Ejection Fraction.

Takahiro Komori1, Kazuo Eguchi1, Toshinobu Saito1

  • 1Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

Journal of Clinical Hypertension (Greenwich, Conn.)
|April 5, 2016
PubMed
Summary

The riser blood pressure (BP) pattern, an abnormal circadian BP rhythm, was more common in patients with heart failure with preserved ejection fraction (HFpEF). This finding suggests a link between abnormal BP patterns during sleep and HFpEF.

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

7.0K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.5K

Related Experiment Videos

Last Updated: Mar 23, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

7.0K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.5K

Area of Science:

  • Cardiology
  • Hypertension Research
  • Heart Failure Studies

Background:

  • Abnormal circadian blood pressure (BP) rhythms, specifically the "riser" pattern (increased BP during sleep), are linked to poor cardiovascular outcomes.
  • The role of ambulatory BP monitoring in heart failure with preserved ejection fraction (HFpEF) remains under-investigated.

Purpose of the Study:

  • To investigate the association between abnormal circadian BP rhythms and HFpEF.
  • To test the hypothesis that the riser BP pattern is more prevalent in HFpEF patients.

Main Methods:

  • A cohort of 508 hospitalized heart failure (HF) patients was analyzed.
  • Patients were categorized into HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) groups.
  • Ambulatory BP monitoring data was used to identify the "riser" BP pattern.

Main Results:

  • The riser BP pattern was observed in 28.9% of HFpEF patients versus 19.9% of HFrEF patients.
  • Multivariable logistic regression revealed that the riser BP pattern was independently associated with HFpEF (OR, 1.73; 95% CI, 1.02-2.91; P=.041).

Conclusions:

  • The "riser" BP pattern, an indicator of abnormal circadian BP rhythm, is significantly associated with HFpEF.
  • These findings highlight the clinical relevance of monitoring BP during sleep in HFpEF management.