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Related Concept Videos

Auditory Pathway01:15

Auditory Pathway

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Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
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Anatomy of the Ear01:16

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Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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The Cochlea01:13

The Cochlea

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Auditory Perception01:17

Auditory Perception

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The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...
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In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
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Dcc Mediates Functional Assembly of Peripheral Auditory Circuits.

Young J Kim1,2, Sheng-zhi Wang1,2, Stephen Tymanskyj3

  • 1Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.

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|April 5, 2016
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Summary

Deleted in colorectal cancer (Dcc) is vital for organizing spiral ganglion neurons and their projections, ensuring proper auditory circuit development and preventing hearing loss.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Auditory Neuroscience

Background:

  • Proper structural organization of spiral ganglion (SG) innervation is essential for hearing.
  • Molecular mechanisms governing the developmental formation of this organization are not well understood.

Purpose of the Study:

  • To investigate the role of deleted in colorectal cancer (Dcc) in the development of spiral ganglion neurons (SGNs) and auditory circuits in the mouse cochlea.

Main Methods:

  • Analysis of Dcc mutant mouse embryos.
  • Examination of SGN organization and projections in peripheral and central auditory pathways.
  • Assessment of synaptic contacts and axon targeting.

Main Results:

  • Dcc is crucial for SGN organization within Rosenthal's canal and projections to auditory targets.
  • Dcc mutation leads to SGN mispositioning, misrouted fibers, and reduced hair cell synapses.
  • Central auditory pathways show abnormal SGN exit and disrupted axon bifurcation in Dcc mutants.

Conclusions:

  • Dcc is necessary for the spatial organization of SGNs and their fibers in both peripheral and central auditory pathways.
  • Dcc controls axon targeting and cell migration during auditory circuit development.
  • Dcc mutations may contribute to sensorineural hearing loss.