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Updated: Mar 23, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Brain Metastasis of Pleural Mesothelioma after a Subarachnoid Hemorrhage

Aya Hirooka1, Akihiro Tamiya, Masaki Kanazu

  • 1Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

Internal Medicine (Tokyo, Japan)
|April 5, 2016
PubMed

Insights

Malignant pleural mesothelioma rarely spreads to the brain. This case report details the first instance of brain metastasis following a subarachnoid hemorrhage, with successful surgical removal.

Area of Science:

  • Oncology
  • Neurology
  • Pathology

Background:

  • Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer.
  • Asbestos exposure is the primary cause of MPM.
  • Brain metastases from MPM are exceptionally uncommon, typically found post-mortem.

Observation:

  • This report presents a unique case of MPM with brain metastasis.
  • The metastasis occurred subsequent to a subarachnoid hemorrhage.
  • The brain lesion was surgically removed.

Findings:

  • This is the first documented case of MPM metastasizing to the brain after a subarachnoid hemorrhage.
  • The surgical intervention for the brain metastasis was performed.

Implications:

  • This case expands the understanding of MPM metastatic patterns.
  • It highlights the possibility of symptomatic brain metastases in MPM patients.
  • Further research into MPM neurotropism and management strategies is warranted.

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