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Updated: Mar 23, 2026

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
Published on: June 28, 2024
Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes
V Cengiz Özalp1, Dilek Çam, Frank J Hernandez
1School of Medicine, Istanbul Kemerburgaz University, Istanbul, 34217, Turkey. cengizozalp@gmail.com.
Abstract:
A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 μM up to 2 mM.
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