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Related Concept Videos

Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

4.4K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.4K
Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Methods of reducing fever01:22

Methods of reducing fever

1.5K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.5K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

15.6K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
15.6K
Decreased Body Temperature01:29

Decreased Body Temperature

1.2K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.2K
Types of Fever01:25

Types of Fever

1.4K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Related Experiment Video

Updated: Mar 23, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

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Is It Exertional Heatstroke or Something More? A Case Report.

Casper Reske-Nielsen1, Katherine Schlosser2, Robert C Pascucci2

  • 1Department of Emergency Medicine, Boston Medical Center, Boston, Massachusetts.

The Journal of Emergency Medicine
|April 5, 2016
PubMed
Summary

Exertional heat stroke can mimic malignant hyperthermia (MH). Prompt recognition and dantrolene sodium administration are crucial for patients with suspected MH, even if presenting with heat illness symptoms.

Keywords:
dantrolene sodiumexertional heat illnessexertional rhabdomyolysisheat strokeheat-related illnessmalignant hyperthermia

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Related Experiment Videos

Last Updated: Mar 23, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
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Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
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Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
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Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

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Area of Science:

  • Emergency Medicine
  • Medical Genetics

Background:

  • Hyperthermia is a key symptom of heat stroke, heat-related illness, and malignant hyperthermia (MH).
  • Malignant hyperthermia is a rare, life-threatening condition requiring immediate recognition and specific treatment.
  • Emerging research links gene mutations to susceptibility for non-anesthetic or exercise-induced MH.

Observation:

  • A 19-year-old male with a family history of MH presented with exertional heat stroke.
  • Despite cooling and fluid resuscitation, the patient experienced worsening rhabdomyolysis.
  • Rhabdomyolysis resolved after administration of dantrolene sodium.

Findings:

  • This case highlights the potential overlap between exertional heat stroke and malignant hyperthermia.
  • Dantrolene sodium proved effective in managing severe rhabdomyolysis in this context.
  • Early recognition of MH in heat stroke patients is critical.

Implications:

  • Emergency physicians must consider malignant hyperthermia in patients with severe heat-related illness, especially those with risk factors.
  • Understanding the link between exertional heat stroke and MH can guide treatment decisions.
  • Prompt dantrolene administration may be life-saving in suspected MH cases presenting as heat illness.