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Updated: Mar 23, 2026
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Molecular genetics and immunohistochemistry characterization of uncommon and recently described renal cell carcinomas
Qiu Rao1, Qiu-Yuan Xia1, Liang Cheng1
11 Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China ; 2 Department of Pathology and Laboratory, Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract:
Renal cell carcinoma (RCC) compromises multiple types and has been emerging dramatically over the recent several decades. Advances and consensus have been achieved targeting common RCCs, such as clear cell carcinoma, papillary RCC and chromophobe RCC. Nevertheless, little is known on the characteristics of several newly-identified RCCs, including clear cell (tubulo) papillary RCC, Xp11 translocation RCC, t(6;11) RCC, succinate dehydrogenase (SDH)-deficient RCC, acquired cystic disease-associated RCC, hereditary leiomyomatosis RCC syndrome-associated RCC, ALK translocation RCC, thyroid-like follicular RCC, tubulocystic RCC and hybrid oncocytic/chromophobe tumors (HOCT). In current review, we will collect available literature of these newly-described RCCs, analyze their clinical pathologic characteristics, discuss their morphologic and immunohistologic features, and finally summarize their molecular and genetic evidences. We expect this review would be beneficial for the understanding of RCCs, and eventually promote clinical management strategies.
Insights
This review details newly identified renal cell carcinoma (RCC) subtypes, including clear cell (tubulo) papillary RCC and Xp11 translocation RCC. It analyzes their pathology, morphology, and genetics to improve understanding and clinical management.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Renal cell carcinoma (RCC) encompasses diverse subtypes, with established knowledge on common forms like clear cell, papillary, and chromophobe RCC.
- Emerging research highlights several newly identified RCC subtypes, yet comprehensive understanding remains limited.
Purpose of the Study:
- To consolidate and analyze existing literature on newly described RCC entities.
- To elucidate the clinical, pathological, morphological, immunohistological, and molecular characteristics of these rare RCCs.
Main Methods:
- Systematic literature review of newly identified RCC subtypes.
- Analysis of clinical pathologic features, morphologic and immunohistologic findings.
- Summary of molecular and genetic evidence for each subtype.
Main Results:
- Detailed characterization of rare RCCs including clear cell (tubulo) papillary RCC, Xp11 translocation RCC, SDH-deficient RCC, and others.
- Identification of distinct morphologic and immunohistochemical profiles for each subtype.
- Compilation of current molecular and genetic data, highlighting key alterations.
Conclusions:
- Enhanced understanding of rare RCC subtypes is crucial for accurate diagnosis and classification.
- This review provides a foundation for future research and improved clinical management strategies for these less common renal tumors.
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