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Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology
11 Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, 2 Department of Urology, Peking University Third Hospital, Beijing 100191, China.
Abstract:
Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high-throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC.
Insights
Epigenetic alterations like DNA methylation and microRNAs are key in clear cell renal cell carcinoma (ccRCC) development. These findings offer new avenues for ccRCC early diagnosis and prognostication.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Clear cell renal cell carcinoma (ccRCC) is a common urologic malignancy.
- ccRCC is characterized by numerous genetic and epigenetic alterations.
Purpose of the Study:
- To review recent findings on epigenetic alterations in ccRCC development and progression.
- To highlight the potential clinical applications of epigenetic profiling in ccRCC.
Main Methods:
- Literature review of recent major findings.
- Focus on DNA methylation, histone modifications, microRNAs, and long noncoding RNAs.
- Discussion of high-throughput technologies for epigenetic analysis.
Main Results:
- Epigenetic alterations play a significant role in ccRCC pathogenesis.
- Specific epigenetic mechanisms discussed include DNA methylation, histone modifications, microRNAs, and lncRNAs.
- High-throughput technologies enable comprehensive epigenetic analysis.
Conclusions:
- Epigenetic profiling shows promise for ccRCC prognostication and early diagnosis.
- Epigenetic analyses are expected to have clinical applications in ccRCC molecular pathology.
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