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Prognostic role of microRNA-150 in various carcinomas: a meta-analysis

Wei Wang1, Xinshuai Wang1, Yali Zhang1

  • 1Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.

Oncotargets and Therapy
|April 5, 2016
PubMed
Abstract

Insights

MicroRNA-150 (miR-150) shows potential as a cancer prognostic biomarker. Elevated miR-150 indicates better overall survival in digestive tract cancers but poorer progression-free survival in various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • MicroRNA-150 (miR-150) has emerged as a potential prognostic biomarker in cancer research.
  • The precise role of miR-150 expression in predicting patient survival across different cancer types remains unclear.

Purpose of the Study:

  • To comprehensively evaluate the prognostic significance of miR-150 expression in the survival of patients diagnosed with various carcinomas.
  • To synthesize existing evidence on the association between miR-150 levels and patient outcomes in oncological settings.

Main Methods:

  • A systematic literature search was conducted to identify relevant studies investigating miR-150 expression and cancer patient survival.
  • Data from eligible studies were extracted, focusing on the relationship between miR-150 and overall survival (OS) and progression-free survival (PFS).
  • A meta-analysis was performed using hazard ratios (HR) to quantify the prognostic impact of miR-150 across different cancer types.

Main Results:

  • The meta-analysis included nine studies encompassing diverse carcinomas.
  • Elevated miR-150 expression was significantly associated with improved overall survival in the digestive tract cancer subgroup (HR = 0.57, 95% CI: 0.37-0.90).
  • Conversely, higher miR-150 levels correlated with poorer progression-free survival in various cancers (HR = 3.08, 95% CI: 2.00-4.75).

Conclusions:

  • miR-150 demonstrates potential as a novel prognostic factor for monitoring cancer prognosis and progression.
  • Further extensive clinical research is warranted to validate these findings due to the current limitations in available data.
Keywords:
carcinomasmeta-analysismicroRNA-150prognosis

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