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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

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New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

Mingjing He1, Zhuan Zhou2, Anil A Shah2

  • 1Department of Cell Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Avenue, HCC2.6c, Pittsburgh, PA 15213 USA ; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan Peoples' Republic of China.

Cell Division
|April 5, 2016
PubMed

Insights

Posttranslational modifications (PTMs) regulate the Hippo signaling pathway, impacting key proteins like YAP/TAZ. Dysregulation of these PTMs is linked to diseases, including cancer, suggesting therapeutic potential.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Medicine

Background:

  • Posttranslational modifications (PTMs) are crucial for signaling protein function.
  • The Hippo signaling pathway plays a vital role in cellular processes.
  • Aberrant PTMs of Hippo pathway components are implicated in human diseases.

Purpose of the Study:

  • To review the regulatory roles of PTMs in the Hippo signaling pathway.
  • To explore the link between PTMs, Hippo pathway dysfunction, and diseases.
  • To discuss potential therapeutic strategies targeting PTMs within the Hippo pathway.

Main Methods:

  • Literature review of PTMs and Hippo signaling.
  • Analysis of PTMs affecting key Hippo pathway components (e.g., YAP/TAZ, LATS1/2).
  • Examination of disease associations with PTM-regulated Hippo signaling.

Main Results:

  • Various PTMs (ubiquitylation, sumoylation, acetylation, methylation) modulate Hippo pathway activity.
  • Key Hippo signaling molecules like YAP/TAZ are subject to extensive PTM regulation.
  • Disrupted PTMs in Hippo pathway components contribute to pathologies such as cancer.

Conclusions:

  • PTMs are critical regulators of the Hippo signaling pathway.
  • Understanding PTMs offers insights into Hippo pathway-related diseases.
  • Targeting PTMs presents a promising avenue for therapeutic interventions in Hippo pathway-associated conditions.
Keywords:
AcetylationCancer and anti-cancer treatmentHippo pathwayMethylationPhosphorylationPosttranslational modificationsSumoylationUbiquitylation

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