Independent association between glycated hemoglobin and arterial stiffness in healthy men
Jin-Won Noh1, Eun-Jung Kim2, Hyun-Ju Seo3
1Department of Healthcare Management and Institute of Global Healthcare Research Eulji University Seongnam Korea.
Insights
High glycated hemoglobin (HbA1c) levels are linked to arterial stiffness in healthy men. This finding highlights HbA1c as a potential indicator for subclinical atherosclerosis and cardiovascular disease risk.
Area of Science:
- Cardiovascular research
- Endocrinology
- Vascular biology
Background:
- Elevated glycated hemoglobin (HbA1c) is a known risk factor for cardiovascular disease (CVD).
- The association between HbA1c and subclinical atherosclerosis phenotypes requires further investigation.
- Understanding these links is crucial for early CVD risk assessment.
Purpose of the Study:
- To evaluate the impact of HbA1c on arterial stiffness and atherosclerosis.
- To assess the relationship between HbA1c and brachial-ankle pulse wave velocity (baPWV) in healthy Korean men.
Main Methods:
- A cohort of healthy adult men undergoing health check-ups was studied.
- Fasting blood samples were analyzed for glucose, HbA1c, lipids, and triglycerides.
- Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV).
- Hierarchical regression analysis was employed to identify risk factors for arterial stiffness.
Main Results:
- Age and HbA1c were significantly associated with baPWV in initial analyses.
- Systolic blood pressure emerged as a stronger predictor of baPWV than diastolic blood pressure.
- In a comprehensive model, age, systolic blood pressure, BMI, and triglycerides were the most significant predictors of arterial stiffness.
Conclusions:
- HbA1c is independently associated with arterial stiffness, a marker of arteriosclerosis.
- Increased arterial stiffness, measured by baPWV, may indicate a higher risk of arteriosclerosis.
- These findings suggest a potential link between HbA1c levels and increased cardiovascular disease risk.
Aims/Introduction:
Many studies have reported that high levels of glycated hemoglobin (HbA1c) are strongly associated with an increased risk of cardiovascular disease. Many researchers have not studied the association of HbA1c with various subclinical atherosclerosis phenotypes. We evaluated the impact of HbA1c on arterial stiffness and atherosclerosis in healthy Korean healthy men.
Materials And Methods:
The study population included healthy adult men who participated in health check-ups. All participants fasted for at least 8 h before taking the blood sample for fasting blood glucose, HbA1c, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Arterial stiffness was measured using brachial-ankle pulse wave velocity. Hierarchical regression analysis allowed us to determine the relationship between brachial-ankle pulse wave velocity (baPWV) and potential risk factors for cardiovascular disease.
Results:
Age and HbA1c were significantly related to baPWV, in model 1. In model 2, blood pressure was added to model 1. Systolic blood pressure was a more significant variable, which was more affected on baPWV than diastolic blood pressure. In the case of model 3, we included all variables regarding arterial stiffness. According to model 3, the most explainable variable was age, and then systolic blood pressure, body mass index and triglyceride, respectively.
Conclusions:
We analyzed the associations between HbA1c, which is one of the risk factors, and arterial stiffness independently. An arterial stiffness measurement using baPWV can show the level of severity of the arteriosclerosis. When the level of stiffness has been increased, we could assume that the risk of arteriosclerosis would be increased. It can also be related to the increase of the risk of cardiovascular disease.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:23Assessment of blood pressure in brachial artery(two-step method)
01:15Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
01:28Factors affecting Blood pressure
Physiological Factors:
01:11Assessing Blood pressure in the Leg
Preparation:
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation