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Related Experiment Videos

Silo-filler's disease.

W W Douglas1, N G Hepper, T V Colby

  • 1Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Mayo Clinic Proceedings
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Exposure to silo gas can cause acute lung injury, including airway edema and alveolar damage, with one fatality. Early corticosteroid therapy may prevent severe outcomes like bronchiolitis obliterans.

Area of Science:

  • Pulmonary Medicine
  • Occupational Health
  • Toxicology

Background:

  • Silo gas, primarily nitrogen oxides, is a significant occupational hazard in agriculture.
  • Exposure can lead to severe respiratory distress and long-term lung damage.

Purpose of the Study:

  • To describe the clinical presentation and outcomes of acute lung injury following silo gas exposure.
  • To review management strategies and recommend preventative measures for silo gas exposure.

Main Methods:

  • Retrospective case series of 17 patients examined after silo gas exposure between 1955 and 1987.
  • Clinical data review, including autopsy findings in one fatal case.

Main Results:

  • 11 of 17 patients developed acute lung injury, with one death attributed to diffuse alveolar damage and pulmonary edema.

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  • Other observed conditions included hypoxemia, airway obstruction, and prolonged respiratory symptoms.
  • Bronchiolitis obliterans was not observed, potentially due to less severe exposure or timely corticosteroid treatment.

    • Conclusions:

    • Acute lung injury from silo gas is a serious occupational hazard requiring prompt medical attention.
    • Prophylactic corticosteroid therapy is recommended for exposed workers.
    • Implementing preventative measures to avoid silo gas exposure is crucial for agricultural workers.