TBS Predict Coronary Artery Calcification in Adults

Area of Science:

• Cardiology
• Osteology
• Radiology

Background:

• Coronary artery calcification (CAC) is a marker of cardiovascular risk.
• Trabecular bone score (TBS) assesses bone microarchitecture, a potential indicator of systemic health.

Purpose of the Study:

• To investigate the association between TBS and the presence and severity of CAC in adults.
• To determine if bone health metrics can predict coronary artery disease.

Main Methods:

• Retrospective analysis of 81 adults who underwent simultaneous coronary CT angiography and bone density assessment.
• CAC was categorized into no, moderate, and high levels.
• Multinomial logistic regression analyzed the relationship between TBS and CAC categories.

Main Results:

• 44.4% of participants had CAC.
• A 1 SD increase in TBS was significantly associated with moderate CAC (OR 2.393, p=0.011).
• No significant association was found between TBS and high CAC (OR 1.026, p=0.928).

Conclusions:

• Elevated TBS correlates with moderate CAC, indicating a potential link between bone microarchitecture and early stages of coronary artery calcification.
• The findings suggest bone remodeling may be associated with the onset of CAC.
• Further research is required to elucidate the underlying pathophysiology and clinical implications.