Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

3
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
3
Disorders of Leukocytes01:27

Disorders of Leukocytes

2.4K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.4K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Viral Meningitis01:18

Viral Meningitis

26
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
26
Sex-linked Disorders01:43

Sex-linked Disorders

110.7K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
110.7K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive genotype-phenotype analysis in POLR3-related disorders.

HGG advances·2025
Same author

BRAT1-Associated Leukodystrophy Exacerbated by Classic Hodgkin Lymphoma-Directed Therapy.

The neurologist·2023
Same author

Beta-Mannosidosis Is a Cause of Hypomyelination.

Pediatric neurology·2023
Same author

Stable Leukoencephalopathy in a Patient With <i>ACTA2</i>-Associated Multisystem Smooth Muscle Disorder.

Neurology·2022
Same author

Expanding the phenotype of ASXL3-related syndrome: A comprehensive description of 45 unpublished individuals with inherited and de novo pathogenic variants in ASXL3.

American journal of medical genetics. Part A·2021
Same author

Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish.

Genetics in medicine : official journal of the American College of Medical Genetics·2021

Related Experiment Video

Updated: Mar 23, 2026

Mouse Models of Periventricular Leukomalacia
06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

30.5K

Adult-Onset Leukoencephalopathies.

Deborah L Renaud

    Continuum (Minneapolis, Minn.)
    |April 5, 2016
    PubMed
    Summary

    Inherited leukoencephalopathies are rare genetic brain disorders that can present in adulthood. Recognizing their clinical and radiographic features aids in diagnosing cognitive decline and differentiating from conditions like multiple sclerosis.

    Area of Science:

    • Neurogenetics
    • Neurology
    • Radiology

    Background:

    • Inherited leukoencephalopathies (ILEs) are a group of rare genetic disorders affecting white matter of the brain.
    • While often diagnosed in childhood, ILEs can manifest or present with milder symptoms in adulthood.

    Observation:

    • Recent advances have identified the molecular underpinnings of adult-onset ILEs.
    • Adult presentations of ILEs previously recognized in pediatric populations are increasingly documented.

    Findings:

    • The clinical and radiographic characteristics of adult-onset ILEs are diverse.
    • Genetic analysis is crucial for identifying specific ILE subtypes.
    • Imaging findings, such as white matter abnormalities, are key diagnostic indicators.

    More Related Videos

    A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice
    04:55

    A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

    Published on: May 11, 2022

    5.0K
    Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
    26:48

    Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

    Published on: July 4, 2007

    18.9K

    Related Experiment Videos

    Last Updated: Mar 23, 2026

    Mouse Models of Periventricular Leukomalacia
    06:24

    Mouse Models of Periventricular Leukomalacia

    Published on: May 18, 2010

    30.5K
    A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice
    04:55

    A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

    Published on: May 11, 2022

    5.0K
    Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
    26:48

    Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

    Published on: July 4, 2007

    18.9K

    Implications:

    • ILEs are an important consideration in the differential diagnosis of adult cognitive decline.
    • Patients may be misdiagnosed or treated for conditions like multiple sclerosis or dementia.
    • Early and accurate diagnosis through clinical and radiographic assessment can guide appropriate management and genetic counseling.