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Updated: Mar 23, 2026

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
Published on: October 28, 2014
Alterations of calcium homeostasis in cancer cells
Saverio Marchi1, Paolo Pinton1
1Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Abstract:
Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca(2+) levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca(2+) homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca(2+) signaling.
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