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Triethylene melamine-induced sister-chromatid exchange in murine lymphocytes exposed in vivo
R E Neft1, H M Schol, D A Casciano
1Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Mutation Research
|April 1, 1989
Abstract:
The induction of sister-chromatid exchange (SCE) by triethylene melamine (TEM), a known animal carcinogen, was investigated in an in vivo exposure/in vitro culture murine lymphocyte assay. Dose-related increases in SCE were observed in B6D2F1 mice following a single i.p. injection of 0.5, 1 or 2 mg/kg TEM. SCE frequencies remained elevated over baseline levels at 24 h post exposure. It is hoped that studies of this nature can determine whether the in vivo/in vitro murine lymphocyte SCE assay is useful for predicting the carcinogenic potential of an agent.