Related Experiment Video
Updated: Mar 23, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
18.1K
In utero Programming of Allergic Susceptibility
Jessica A Grieger1, Vicki L Clifton, Astrud R Tuck
1Robinson Research Institute and School of Medicine, University ofAdelaide, Adelaide, S.A., Australia.
International Archives of Allergy and Immunology
|April 5, 2016
Summary
Prenatal exposures significantly impact childhood allergy development. Identifying these early life risk factors and protective elements is crucial for preventing the rising allergy pandemic in children.
Area of Science:
- Immunology
- Pediatrics
- Public Health
Background:
- Allergy affects 30-40% of the global population, with incidence rising, particularly in children.
- Early life events, especially in utero exposures, are strongly linked to allergy development.
- Up to 18% of children experience respiratory, food, or skin allergies before age 18.
Purpose of the Study:
- To review prenatal risk factors for childhood allergy.
- To outline potential mechanisms linking prenatal exposures to allergy development.
Main Methods:
- A comprehensive literature review was conducted.
- The review focused on prenatal risk factors and underlying mechanisms of childhood allergy.
Main Results:
- Maternal smoking, preterm birth, and Cesarean delivery are associated with increased allergy risk.
- In utero growth restriction, healthy maternal diet, and larger family size appear protective.
- Mechanisms for protective factors require further investigation.
Conclusions:
- Defining prenatal mechanisms altering fetal immune programming is essential.
- Identifying specific targets for antenatal interventions is necessary to combat the allergy pandemic.
- Understanding early life influences is key to preventing childhood allergies.
More Related Videos
Related Concept Videos
02:06Allergic Reactions
33.4K
Overview
33.4K
01:07Teratogenicity
4.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
01:21Intrauterine Drug Delivery Systems
123
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
123
01:22Development of Immunocompetence
1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K