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Updated: Mar 23, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Multifocal low-grade central osteosarcoma: a rare case.

Richard Boyle¹, Bruno Giuffre², S Fiona Bonar³

¹Department of Orthopaedics, The Chris O'Brien Lifehouse and Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia. Rich_boyle@hotmail.com.

Skeletal Radiology

|April 6, 2016

Summary

Low-grade central osteosarcoma (LGCOS), a rare bone cancer, can present multifocally. Close monitoring of incidental findings is crucial for early detection and management of this uncommon condition.

Keywords:

Low grade central osteosarcoma Multifocal Multimodal imaging Osteosarcoma Synchronous

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Last Updated: Mar 23, 2026

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Published on: October 14, 2016

Area of Science:

Orthopedic Oncology
Skeletal Radiology

Background:

Low-grade central osteosarcoma (LGCOS) is an uncommon malignant bone tumor.
Multifocal presentation of LGCOS is exceptionally rare.

Observation:

A case of multifocal LGCOS in two distinct skeletal locations is presented.
Lesions were incidental findings during imaging for unrelated trauma.
Initial imaging revealed small, seemingly innocuous, and clinically quiescent lesions.

Findings:

The multifocal nature of LGCOS was confirmed.
The lesions demonstrated slow growth or stability over time.
Multimodal surveillance imaging was essential for tracking lesion evolution.

Implications:

Highlights the importance of recognizing LGCOS, even when presenting as incidental findings.
Emphasizes the diagnostic value of vigilant, interval-based imaging surveillance.
Suggests that multifocal LGCOS may have an indolent clinical course requiring careful monitoring.