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In Vitro Activity of Eravacycline against Carbapenem-Resistant Enterobacteriaceae and Acinetobacter baumannii
David M Livermore1, Shazad Mushtaq2, Marina Warner2
1Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health England, London, United Kingdom Norwich Medical School, University of East Anglia, Norwich, United Kingdom d.livermore@uea.ac.uk.
Abstract:
Eravacycline and comparators were tested against carbapenem- and tigecycline-resistant Enterobacteriaceae and Acinetobacter isolates received at the United Kingdom's national reference laboratory. Eravacycline MICs correlated closely with those of tigecycline but mostly were around 2-fold lower; both molecules retained full activity against isolates with high-level tetracycline and minocycline resistance. MIC90s of eravacycline and tigecycline were raised ca. 2-fold for carbapenem-resistant Enterobacteriaceae compared with carbapenem-susceptible controls, probably reflecting subsets of isolates with increased efflux.
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