Anti-Co3 and severe hemolytic disease of the newborn

Irregular antibodies have been described to cause hemolytic disease of the newborn of varying severity. A case of anti-Colton 3 causing moderate to severe hemolysis in the newborn in two pregnancies is described. Only two cases of hemolytic disease of the newborn have been previously described; these resulted in mild hemolysis. The management of the condition is reviewed in the light of the current management of hemolytic disease of the newborn.