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Related Experiment Video

Updated: Mar 23, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
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ASK1 signalling regulates brown and beige adipocyte function.

Kazuki Hattori1, Isao Naguro1, Kohki Okabe2,3

  • 1The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Nature Communications
|April 6, 2016
PubMed
Summary

The protein kinase ASK1 regulates brown and beige adipocyte function. ASK1 signaling is crucial for metabolic health, impacting thermogenesis and energy consumption in both cells and whole organisms.

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Author Spotlight: Unraveling the Molecular Mechanisms of Brown and Beige Adipocyte Regulation
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Area of Science:

  • Metabolic diseases
  • Cellular signaling
  • Adipocyte biology

Background:

  • Adult humans possess active brown and beige adipocytes, offering potential therapeutic targets for metabolic diseases.
  • Activating these adipocytes presents a promising strategy for treating various metabolic disorders.

Purpose of the Study:

  • To investigate the role of the protein kinase ASK1 in regulating brown and beige adipocyte function.
  • To elucidate the molecular mechanisms by which ASK1 influences adipocyte activity and gene expression.

Main Methods:

  • Studied the PKA-ASK1-p38 signaling axis in brown and white adipocytes.
  • Utilized global and fat-specific ASK1-deficient mouse models.
  • Assessed metabolic responses, including thermogenesis and oxygen consumption.

Main Results:

  • The PKA-ASK1-p38 pathway is activated by cAMP signaling, promoting the expression of key genes like Ucp1 in adipocytes.
  • ASK1 deficiency in mice impaired cellular and whole-body metabolic responses, including thermogenesis and oxygen consumption.
  • ASK1 signaling is essential for maintaining brown and beige adipocyte gene expression and overall function.

Conclusions:

  • The ASK1 signaling axis is a critical regulator of brown and beige adipocyte gene expression and function.
  • Targeting ASK1 may offer a therapeutic approach for metabolic diseases by modulating adipocyte activity.