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Acid-mediated topological control in a functionalized foldamer.

Peter C Knipe1, Sam Thompson1, Andrew D Hamilton2

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Researchers synthesized chiral foldamers that change shape in response to acid. These pyridine/imidazolidin-2-one molecules transition between linear and helical structures, offering new ways to control molecular function.

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Area of Science:

  • Supramolecular Chemistry
  • Organic Synthesis
  • Materials Science

Background:

  • Molecular conformational changes are key to controlling molecular structure and function.
  • Foldamers are polymers that adopt defined structures, mimicking proteins.

Purpose of the Study:

  • To synthesize novel chiral, surface-functionalized foldamers based on pyridine and imidazolidin-2-one units.
  • To investigate the acid-mediated conformational transitions of these foldamers between linear and helical states.

Main Methods:

  • Synthesis of chiral oligomeric pyridine/imidazolidin-2-one foldamers.
  • Characterization of foldamer structure and conformation using spectroscopic and analytical techniques.
  • Acid-triggered studies to monitor conformational changes.

Main Results:

  • Successful synthesis of novel chiral foldamers with pyridine and imidazolidin-2-one components.
  • Demonstration of acid-mediated transitions between distinct linear and helical topologies.
  • Evidence of controlled conformational switching in response to pH changes.

Conclusions:

  • Chiral pyridine/imidazolidin-2-one foldamers can undergo reversible conformational changes.
  • Acid-responsive foldamers offer a platform for developing dynamic molecular systems.
  • These findings open avenues for designing smart materials and molecular switches.