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Epigenetic Markers to Predict Conversion From Gestational Diabetes to Type 2 Diabetes

Agnes A Michalczyk1, James A Dunbar1, Edward D Janus1

  • 1Centre for Cellular and Molecular Biology (A.A.M., M.L.A.), School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia 3125; Deakin Population Health Strategic Research Centre (J.A.D., D.A.), Faculty of Health, Deakin University, Burwood, Victoria, Australia 3125; University of Melbourne (E.D.J.) Western Centre for Health Research and Education, Western Health, St Albans, Victoria, Australia 3021; Lee Kong Chian School of Medicine (J.D.B.), Singapore, 308232; Faculty of Medicine, Nursing and Health Sciences (P.R.E.), Monash University, Victoria, Australia 3168; and Department of Health & Human Services (M.J.A.), Victoria, Australia 3000.

The Journal of Clinical Endocrinology and Metabolism
|April 6, 2016
PubMed
Summary

Epigenetic markers, specifically H3K27 and H3K4 dimethylation, were lower in women who developed type 2 diabetes after gestational diabetes (GDM). These markers may predict GDM to type 2 diabetes conversion.

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