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Published on: June 26, 2019
Choroidal metastasis as a presenting manifestation of a lung adenocarcinoma with response to afatinib
M Contreras-Díaz1, A Medina-Tapia1, G Martínez-Bernal2
1Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
Case Report:
We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up.
Discussion:
Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation.
Insights
Choroidal metastasis can be an early indicator of lung cancer. This case report shows afatinib effectively treated choroidal metastasis in non-small cell lung cancer with an EGFR mutation.
Area of Science:
- Ophthalmology
- Oncology
- Pulmonology
Background:
- Choroidal tumors can present as a metastasis of primary lung cancer.
- Non-small cell lung adenocarcinoma (NSCLC) is a common type of lung cancer.
- EGFR mutations are prevalent in NSCLC and can be targeted with specific therapies.
Purpose of the Study:
- To report a case of choroidal metastasis from NSCLC.
- To evaluate the efficacy of afatinib in treating choroidal metastasis.
- To emphasize the significance of systemic evaluation for choroidal tumors.
Main Methods:
- Case presentation of a 55-year-old man with NSCLC and decreased visual acuity.
- Diagnostic workup revealing unilateral choroidal metastasis.
- Treatment with afatinib and one-year follow-up.
Main Results:
- The patient's choroidal metastasis showed complete regression after one year of afatinib treatment.
- Afatinib demonstrated efficacy in managing ocular metastasis.
- The case underscores the potential for choroidal metastasis to be the initial presentation of lung cancer.
Conclusions:
- Choroidal metastasis can be the first sign of underlying lung cancer.
- Systemic evaluation is crucial for patients diagnosed with choroidal tumors.
- Afatinib is an effective treatment for EGFR-mutated lung adenocarcinoma with choroidal metastasis.
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