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Neurobrucellosis in children.

M M Lubani1, K I Dudin, G F Araj

  • 1Department of Pediatrics, Farwania Hospital, Kuwait.

The Pediatric Infectious Disease Journal
|February 1, 1989
PubMed
Summary
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Neurobrucellosis, a rare nervous system infection, was diagnosed in nine children. Prompt antibiotic treatment led to successful recovery with no long-term effects in any patient.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Nervous system involvement in brucellosis is uncommon in pediatric cases.
  • Brucellosis can present with diverse neurological manifestations.

Purpose of the Study:

  • To describe the clinical presentation, diagnosis, and treatment outcomes of neurobrucellosis in children.
  • To highlight the importance of considering brucellosis in pediatric neurological disorders.

Main Methods:

  • Case series of nine pediatric patients diagnosed with neurobrucellosis.
  • Diagnostic methods included serological tests (Brucella microagglutination test, ELISA for IgM, IgG, IgA) and microbial cultures (blood, cerebrospinal fluid).
  • Clinical data on neurological presentations and treatment regimens were collected.

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Main Results:

  • The nine children presented with various forms of central nervous system involvement, including meningitis, encephalitis, and meningoencephalitis.
  • Elevated Brucella antibody titers and positive microbial cultures confirmed the diagnosis.
  • Cerebrospinal fluid analysis revealed lymphocytic pleocytosis, altered protein, and glucose levels.
  • Combination antibiotic therapy, including tetracyclines, streptomycin, and rifampin, resulted in successful treatment.

Conclusions:

  • Neurobrucellosis in children, though rare, is a treatable condition with appropriate antimicrobial therapy.
  • Early diagnosis and prompt treatment are crucial to prevent relapses, mortality, and sequelae.
  • This case series underscores the need for increased awareness of neurobrucellosis in pediatric neurology.