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Related Experiment Video

Updated: Mar 23, 2026

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BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION: A CASE REPORT.

Tarek Alasil1, Patrick A Coady, Sirine Koudsi

  • 1*Department of Ophthalmology, Ophthalmic Oncology Program, Smilow Cancer Hospital at Yale New Haven, Yale University School of Medicine, New Haven, Connecticut; and †Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut.

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Summary
This summary is machine-generated.

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome associated with ovarian cancer. This case highlights the potential of plasmapheresis in managing this condition and preserving vision.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Background:

  • Metastatic ovarian cancer can present with unusual paraneoplastic syndromes.
  • Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare condition linked to certain cancers.

Observation:

  • A 59-year-old woman with a history of metastatic ovarian cancer developed worsening vision and photophobia.
  • Ophthalmic examination revealed characteristic findings including pigmented lesions, choroidal thickening, and exudative retinal detachment.

Findings:

  • The patient was diagnosed with BDUMP secondary to metastatic ovarian carcinoma.
  • Fluorescein angiography showed a distinctive 'giraffe-like' pattern.
  • Optical coherence tomography confirmed exudative retinal detachment.

Implications:

  • BDUMP may arise from cross-reactivity between ovarian tumor antigens and ocular melanocytes.
  • Plasmapheresis is a potential treatment to reduce circulating antibodies, preserve vision, and improve quality of life.
  • This case underscores the importance of recognizing BDUMP as a paraneoplastic manifestation of ovarian cancer.