The clinical trial in multidisciplinary research.

Area of Science:

• Dental research methodology
• Translational science in dentistry

Background:

• Dental research traditionally follows separate epidemiological and laboratory paths.
• Epidemiological studies identify correlations, while lab experiments provide hypotheses.
• Bridging this gap requires human studies to validate findings.

Purpose of the Study:

• To explore methodologies for integrating diverse dental research findings.
• To demonstrate how clinical trials can connect basic science with epidemiological data.
• To propose an ideal model for advancing dental research.

Main Methods:

• Review of existing dental research methodologies.
• Description of experimental studies on pellicle and plaque formation.
• Emphasis on the role of controlled clinical trials.

Main Results:

• Clinical trials effectively bridge the gap between laboratory hypotheses and epidemiological observations.
• Experimental studies on pellicle and plaque formation serve as examples of this integration.
• Controlled human studies are crucial for validating research findings.

Conclusions:

• An ideal dental research model involves problem identification, laboratory investigation, in vivo testing, and controlled clinical trials.
• This integrated approach enhances the applicability of research to human dental health.
• Controlled studies in humans are essential for definitive solutions in dental research.