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Updated: Mar 23, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

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Encoding four gene expression programs in the activation dynamics of a single transcription factor

Anders S Hansen1, Erin K O'Shea2

  • 1Department of Molecular Cell Biology, HHMI, Li Ka Shing Center, University of California, Berkeley, CA 94720, USA; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Northwest Laboratory, 52 Oxford Street, Cambridge, MA 02138, USA; Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Northwest Laboratory, 52 Oxford Street, Cambridge, MA 02138, USA.

Current Biology : CB
|April 6, 2016
PubMed
Summary

Cellular signaling uses a single transcription factor to control gene expression. This study shows that by altering the factor's activation dynamics, scientists can trigger four distinct gene programs.

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