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NELL-1 expression in tumors of cartilage
Jia Shen1, Gregory LaChaud2, Swati Shrestha1
1Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
Background/Aims:
NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors.
Methods:
Immunohistochemical expression was examined in human pathologic specimens.
Results:
Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade.
Conclusion:
In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.
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