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Updated: Mar 23, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
The challenge to improve the response of biomaterials to the physiological environment
Nicholas A Peppas1, John R Clegg2
1McKetta Department of Chemical Engineering,; Department of Biomedical Engineering,; Institute for Biomaterials, Drug Delivery and Regenerative Medicine; Department of Surgery and Perioperative Care, Dell Medical School and; Division of Pharmaceutics, College of Pharmacy, University of Texas at Austin.
Abstract:
New applications of biomaterials often require advanced structures containing synthetic and natural components that are tuned to provide properties unique to a specific application. We discuss how structural characteristics of biomaterials, especially hydrophilic ones, can be used in conjunction with non-ideal thermodynamics to develop advanced medical systems. We show a number of examples of biocompatible, intelligent biomaterials that can be used for organ replacement, biosensors, precise drug delivery over days or weeks, and regenerative medicine.

