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Published on: January 29, 2020
The Quest toward limb regeneration: a regenerative engineering approach
Cato T Laurencin1, Lakshmi S Nair2
1Department of Orthopaedic Surgery, Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030, USA,; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA.
Regenerative Engineering offers a novel approach to regrow human limbs by combining advances in stem cell science, material science, and surgical techniques. This strategy aims to overcome current limitations in wound healing and address the challenge of limb loss.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Stem Cell Biology
- Surgical Innovation
Background:
- Human limb loss presents a significant clinical challenge with limited therapeutic options.
- Current wound healing processes do not support complete tissue regeneration.
- Recent scientific advancements offer new possibilities for regenerative strategies.
Purpose of the Study:
- To explore the potential of Regenerative Engineering for human limb regeneration.
- To discuss the convergence of multiple scientific disciplines for this goal.
- To outline translational strategies for developing regenerative therapies.
Main Methods:
- Leveraging a 'regenerative toolbox' comprising stem cell science, material science, and engineering.
- Integrating knowledge from physics and novel surgical approaches.
- Developing innovative translational strategies based on convergent research.
Main Results:
- The convergence of diverse scientific fields provides a robust framework for limb regeneration.
- A multidisciplinary approach is essential to overcome the complexity of regenerating a human limb.
- The development of novel strategies is facilitated by the integration of existing scientific knowledge.
Conclusions:
- Regenerative Engineering offers a promising pathway towards achieving human limb regeneration.
- The integration of stem cell science, material science, engineering, and surgery is key.
- This approach holds the potential to address the clinical grand challenge of limb loss.
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