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Related Concept Videos

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Related Experiment Video

Updated: Mar 23, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Evaluation of post-mortem lateral cerebral ventricle changes using sequential scans during post-mortem computed

Iwao Hasegawa1,2,3, Akinobu Shimizu4, Atsushi Saito4

  • 1Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld 34, Hamburg, 22529, Germany. i-hase@is.icc.u-tokai.ac.jp.

International Journal of Legal Medicine
|April 7, 2016
PubMed
Summary
This summary is machine-generated.

Post-mortem computed tomography (CT) scans reveal changes in lateral cerebral ventricles (LCVs). Cerebrospinal fluid (CSF) radiodensity increases over time, potentially indicating the post-mortem interval (PMI).

Keywords:
Lateral cerebral ventriclePost mortem intervalPost-mortem changePost-mortem computed tomographySequential scan

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Area of Science:

  • Forensic Radiology
  • Post-mortem Imaging
  • Neuropathology

Background:

  • Accurate determination of the post-mortem interval (PMI) is crucial in forensic investigations.
  • Traditional methods for PMI estimation have limitations.
  • Non-invasive imaging techniques offer potential for objective PMI assessment.

Purpose of the Study:

  • To evaluate post-mortem changes in the lateral cerebral ventricles (LCVs) using computed tomography (CT).
  • To investigate the potential of cerebrospinal fluid (CSF) radiodensity changes as an indicator of PMI.

Main Methods:

  • Sequential CT scans were performed on three cadavers for up to 24 hours post-mortem.
  • LCV volume and Hounsfield units (HU) of CSF were measured.
  • Changes in LCVs and CSF radiodensity were correlated with the PMI.

Main Results:

  • LCV volume progressively decreased over time.
  • Average CSF Hounsfield units (HU) within the LCVs progressively increased.
  • The rate of HU increase was proportional to the PMI.

Conclusions:

  • Early longitudinal radiodensity changes in CSF may serve as a potential indicator of PMI.
  • Sequential CT imaging reveals post-mortem alterations in the CSF space.
  • Further research is needed to validate CSF changes against established PMI indicators.