Neuropsychiatric Issues in Parkinson's Disease
Jeffrey W Cooney1, Mark Stacy2
1Duke University School of Medicine, 932 Morreene Rd., Durham, NC, 27705, USA.
Current Neurology and Neuroscience Reports
|April 7, 2016
Summary
Parkinson's Disease often causes cognitive and neuropsychiatric symptoms that significantly impact quality of life, affecting patients more than motor symptoms. These symptoms stem from brain changes and treatment side effects, impacting mood, cognition, and behavior.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Cognitive and neuropsychiatric symptoms are prevalent in Parkinson's Disease (PD).
- These symptoms can significantly impair patient quality of life, sometimes more than motor deficits.
- They arise from both the disease pathology and treatment side effects.
Purpose of the Study:
- To review the current understanding of neuropsychiatric symptoms in Parkinson's Disease.
- To differentiate symptoms related to PD progression from those caused by treatment.
Main Methods:
- Literature review of studies on cognitive and neuropsychiatric symptoms in Parkinson's Disease.
- Analysis of symptom presentation in relation to disease stage and treatment.
Main Results:
- Mood symptoms (depression, anxiety, apathy) can precede motor symptoms.
- Cognitive impairment, dementia, and psychosis are more common in later PD stages.
- Treatment-related symptoms include impulse control disorders and psychosis.
Conclusions:
- Neuropsychiatric symptoms are a core feature of Parkinson's Disease.
- Understanding the origins of these symptoms is crucial for effective management.
- Comprehensive assessment and management strategies are needed for PD patients.
Related Concept Videos
01:24Parkinson's Disease: Treatment
1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
01:15Parkinson's Disease: Overview
2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
01:37Neural Regulation
44.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.6K
01:28Disorders of the Nervous Tissue
3.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.0K
01:21Antipsychotic Drugs: Therapeutic Uses and Side Effects
1.1K
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
1.1K
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K