Intranasal T-LysYal® as adjunctive therapy for patients after functional endoscopic sinus surgery

Area of Science:

• Otolaryngology
• Biomaterials Science
• Immunology

Background:

• Functional Endoscopic Sinus Surgery (FESS) is a common procedure for upper airway disorders.
• Hyaluronic acid (HA) possesses reparative, anti-inflammatory, and immune-modulating properties.
• A novel intranasal HA formulation, T-LysYal®, combines lysine hyaluronate, thymine, and sodium chloride.

Purpose of the Study:

• To evaluate the efficacy of intranasal T-LysYal® in reducing symptoms, endoscopic features, and nasal cytology post-FESS.
• To compare the effects of T-LysYal® with isotonic saline solution in FESS patients.

Main Methods:

• A randomized study involving 83 patients undergoing FESS.
• Patients received either isotonic saline or intranasal T-LysYal® plus saline for 4 weeks.
• Assessments included symptom severity, endoscopic evaluation, and nasal cytology at baseline, post-treatment, and follow-up.

Main Results:

• Intranasal T-LysYal® significantly reduced symptom severity compared to saline.
• Endoscopic features and inflammatory cell counts were significantly lower in the T-LysYal® group.
• Treatment effects were sustained at the 4-week follow-up.

Conclusions:

• Intranasal T-LysYal® demonstrates significant efficacy in improving patient outcomes after FESS.
• The formulation offers a long-lasting beneficial effect on post-surgical recovery.
• T-LysYal® represents a promising therapeutic option for post-FESS management.