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Averting the legacy of kidney disease-focus on childhood

Julie R Ingelfinger1, Franz Schaefer2, Kamyar Kalantar-Zadeh3

  • 1Harvard Medical School, USA.

Jornal Brasileiro De Nefrologia
|April 7, 2016
PubMed

Insights

Childhood kidney disease, often stemming from congenital issues, can lead to adult chronic kidney disease (CKD). Early detection and intervention are crucial for at-risk children to prevent or treat kidney disease effectively.

Area of Science:

  • Pediatric Nephrology
  • Public Health

Background:

  • Childhood kidney disease primarily involves congenital anomalies and inherited disorders, unlike adult CKD where glomerulopathies and diabetes are more common.
  • Acute kidney injury in children can lead to long-term sequelae, including hypertension and chronic kidney disease (CKD).
  • Premature birth and being small-for-date newborns increase the risk of developing CKD later in life.

Discussion:

  • Early identification of kidney disease in high-risk children is essential for timely prevention and treatment.
  • Advanced CKD in childhood is treatable, with children often responding better to kidney replacement therapy than adults.
  • Disparities in healthcare access necessitate efforts to ensure effective treatment for all children with kidney disease, regardless of location or economic status.

Key Insights:

  • Congenital anomalies and inherited disorders are the leading causes of CKD in children.
  • Early life factors significantly influence the risk of developing CKD later in life.
  • Pediatric CKD management requires a focus on early detection, prevention, and equitable access to care.

Outlook:

  • World Kidney Day aims to raise public, policymaker, and caregiver awareness of childhood kidney disease needs and treatment possibilities.
  • Continued research and advocacy are vital to improve outcomes for children with kidney disease globally.
  • Addressing healthcare disparities is critical to ensure all children receive necessary kidney disease care.

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