Related Experiment Video

Updated: Mar 23, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

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Pneumatosis Coli in Complex Neurodisability: An Increasingly Problematic Disease Spectrum and Proposed Management

Rebecca West1, Dipanker Dass, Santosh Mordekar

  • 1*Paediatric Surgical Unit †Department of Neurology, Sheffield Children's National Health Service Trust ‡Department of Gastroenterology, Sheffield Children's Hospital, Sheffield, UK.

Journal of Pediatric Gastroenterology and Nutrition
|April 7, 2016
PubMed

Insights

Laparoscopically assisted defunctioning ileostomy significantly improved symptoms and feeding tolerance in children with neurodisability and pneumatosis coli. This approach offers a promising alternative to long-term parenteral nutrition.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Clinical Case Series

Background:

  • Complex neurodisability and feed intolerance present significant management challenges in pediatric patients.
  • Pneumatosis coli, gas in the colon wall, can be associated with severe gastrointestinal dysfunction.

Observation:

  • This case series evaluated 4 children with neurodisability, feed intolerance, and pneumatosis coli.
  • All patients underwent a laparoscopically assisted defunctioning ileostomy.

Findings:

  • The surgical intervention led to substantial improvements in symptoms and feed tolerance for all 4 children.
  • This minimally invasive approach effectively managed the complex gastrointestinal issues.

Implications:

  • Laparoscopically assisted defunctioning ileostomy is a promising treatment to reduce long-term parenteral nutrition dependence.
  • Potential long-term risk of disuse colitis in the defunctioned bowel requires consideration.

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