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Coagulation Gene Expression Profiling in Infants With Necrotizing Enterocolitis.

Stefano Giuliani1, Yew-Wei Tan, Dongling Zheng

  • 1*Department of Paediatric and Neonatal Surgery, St George's University Hospitals NHS Foundation Trust †Human Genetics Research Centre, Institute of Cardiovascular and Cell Sciences, St George's University of London ‡Department of Neonatal Intensive Care Unit, St George's University Hospitals NHS Foundation Trust, London, UK.

Journal of Pediatric Gastroenterology and Nutrition
|April 7, 2016
PubMed
Summary

Gene expression changes in coagulation and anticoagulation systems were observed in premature neonates with necrotizing enterocolitis (NEC). These findings may reveal biomarkers for disease progression and associated coagulopathy.

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Area of Science:

  • Neonatal Medicine
  • Molecular Biology
  • Hematology

Background:

  • Coagulopathy and mesenteric thrombosis are frequent complications in premature neonates diagnosed with necrotizing enterocolitis (NEC).
  • Understanding the molecular underpinnings of these complications is crucial for improving patient outcomes.

Purpose of the Study:

  • This pilot study investigated alterations in gene expression within the coagulation and anticoagulation systems in neonates with NEC.
  • The study aimed to identify potential molecular biomarkers associated with NEC and its progression.

Main Methods:

  • A pathway-specific quantitative polymerase chain reaction array was employed to analyze the expression of 94 genes.
  • Gene expression was compared between 11 neonates with NEC (Bell stages 2-3) and two control groups (10 healthy controls and 12 sepsis controls).

Main Results:

  • Twelve genes related to coagulation and anticoagulation showed significant expression changes in NEC patients compared to healthy controls.
  • Upregulated genes (e.g., neutrophil elastase, F12) suggested a procoagulant effect, while downregulated genes (e.g., MFGE8, F2RL1) indicated reduced fibrinolysis and endothelial regeneration.
  • A significant difference in F2RL1 expression was noted between NEC and sepsis groups.

Conclusions:

  • The study identified potential gene expression biomarkers linked to coagulopathy and disease progression in NEC.
  • Further investigation into the transcriptional procoagulant status is warranted to elucidate mechanisms behind intestinal necrosis and multiorgan failure in NEC.